. 2017 Jan 5;72(4):1152–1162. doi: 10.1093/jac/dkw545

Table 4.

Meta-analysis of significantly associated SNPs in the discovery and replication cohorts

SNP	Gene	Phenotype	Cohort	Case/ control	n	MAF	Logistic regression		Meta-analysis
SNP	Gene	Phenotype	Cohort	Case/ control	n	MAF	P	OR (95% CI)	P	OR (95% CI)
rs34213790	3′ of HLA-B	all hypersensitivity	discovery	case	151	0.45	1.15 × 10⁻⁶	2.34 (1.66–3.30)	–	–
rs34213790	3′ of HLA-B	all hypersensitivity	discovery	control	182	0.37	1.15 × 10⁻⁶	2.34 (1.66–3.30)	–	–
			replication	case	27	0.50	0.10	1.56 (0.94–2.60)	6.69 × 10⁻⁷	2.06 (1.55–2.74)
			replication	control	60	0.38	0.10	1.56 (0.94–2.60)	6.69 × 10⁻⁷	2.06 (1.55–2.74)
rs5010528	HLA-C	SJS/TEN	discovery	case	51	0.36	4.13 × 10⁻⁶	4.75 (2.45–9.22)	–	–
rs5010528	HLA-C	SJS/TEN	discovery	control	182	0.14	4.13 × 10⁻⁶	4.75 (2.45–9.22)	–	–
			replication	case	38	0.38	6.03 × 10⁻³	5.12 (1.60–16.41)	8.47 × 10⁻⁸	4.84 (2.71–8.61)
			replication	control	68	0.12	6.03 × 10⁻³	5.12 (1.60–16.41)	8.47 × 10⁻⁸	4.84 (2.71–8.61)
rs6139258	RNF24	DILI	discovery	case	21	0.19	6.64 × 10⁻⁶	14.42 (4.52–46.04)	–	–
rs6139258	RNF24	DILI	discovery	control	182	0.02	6.64 × 10⁻⁶	14.42 (4.52–46.04)	–	–
			replication	case	42	0.07	0.03	11.17 (1.29–96.38)	5.66 × 10⁻⁷	13.62 (4.90–37.84)
			replication	control	68	0.01	0.03	11.17 (1.29–96.38)	5.66 × 10⁻⁷	13.62 (4.90–37.84)

Data shown are for analysis undertaken with covariates (CD4+ cell count) included in the regression model (except DILI) for both the discovery and replication cohorts (± supplementary cohort for SJS/TEN and DILI).