Table 1.
Disease | Dataset | Subject
|
rs73366469 (C/Ta)
|
rs117026326 (T/Ca)
|
p.Arg90His (A/Ga)
|
p.Ser99Gly (G/Aa)
|
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---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MAFb (%)
|
P | OR | Pc | MAFb (%)
|
P | OR | Pc | MAFb (%)
|
P | OR | MAFb (%)
|
P | OR | Pc | ||||||||
Case | Control | Case | Control | Case | Control | Case | Control | Case | Control | |||||||||||||
SLE | AfrAm* | 474 | 315 | 18.5 | 19.5 | 0.66 | 0.94 | 0.43 | 0.0 | 1.00 | 15.7 | 8.3 | 2.9×10−5 | 2.02 | 40.1 | 39.4 | 0.78 | 1.03 | ||||
| ||||||||||||||||||||||
SLE | Chinese-1 | 436 | 586 | 29.7 | 13.9 | 1.7×10−14 | 2.66 | 0.57 | 28.1 | 11.4 | 1.8×10−17 | 3.18 | 0.27 | 38.1 | 15.6 | 2.6×10−23 | 3.35 | 43.2 | 26.8 | 1.6×10−13 | 2.22 | 0.70 |
SLE | Chinese-2 | 746 | 1034 | 30.0 | 15.2 | 6.5×10−22 | 2.48 | 0.046 | 27.1 | 11.9 | 2.3×10−24 | 2.82 | 0.093 | 41.6 | 16.7 | 1.5×10−41 | 3.27 | 46.5 | 28.2 | 1.6×10−22 | 2.13 | 0.21 |
SLE | Meta-Chinese | 1182 | 1620 | 9.2×10−35 | 2.55 | 4.4×10−40 | 2.94 | 4.2×10−63 | 3.30 | 2.1×10−34 | 2.16 | |||||||||||
| ||||||||||||||||||||||
SLE | Korean* | 611 | 685 | 30.0 | 11.4 | 3.3×10−27 | 3.25 | 0.18 | 46.6 | 18.1 | 2.6×10−43 | 3.82 | 52.4 | 30.5 | 3.2×10−26 | 2.47 | 0.052 | |||||
SLE | Meta-Asians | 1793 | 2305 | 2.0×10−65 | 3.05 | 3.1×10−104 | 3.47 | 1.5×10−58 | 2.26 | |||||||||||||
| ||||||||||||||||||||||
SLE | EurAm-1* | 612 | 485 | 10.8 | 8.5 | 0.036 | 1.37 | 0.64 | 2.4 | 0.72 | 6.4×10−3 | 3.25 | 0.59 | 5.5 | 2.1 | 9.5×10−5 | 2.83 | 17.8 | 13.0 | 3.9×10−3 | 1.44 | 0.12 |
SLE | EurAm-2* | 736 | 446 | 11.9 | 8.5 | 0.012 | 1.46 | 0.25 | 2.4 | 0.67 | 6.1×10−3 | 3.51 | 0.29 | 6.0 | 2.4 | 5.0×10−4 | 2.42 | 18.6 | 13.1 | 5.5×10−4 | 1.53 | 0.057 |
SLE | Meta-EurAm | 1348 | 931 | 1.1×10−3 | 1.42 | 1.1×10−4 | 3.37 | 1.9×10−7 | 2.61 | 7.3×10−6 | 1.49 | |||||||||||
| ||||||||||||||||||||||
SS | Chinese-SS | 449 | 469 | 26.2 | 14.7 | 4.6×10−9 | 2.03 | 0.29 | 37.8 | 18.3 | 7.2×10−17 | 2.45 | 41.5 | 29.1 | 9.7×10−8 | 1.68 | 0.017 | |||||
SS | EurAm-SS* | 302 | 931 | 2.0 | 0.70 | 7.3×10−3 | 3.12 | 0.36 | 4.8 | 2.2 | 9.7×10−4 | 2.35 | 15.4 | 13.1 | 0.20 | 1.19 | 0.93 | |||||
| ||||||||||||||||||||||
RA | Korean-RA | 836 | 685 | 26.6 | 18.1 | 2.5×10−8 | 1.65 | 35.2 | 30.5 | 2.0×10−3 | 1.27 | 0.94 |
minor/major allele,
minor allele frequency,
P value after conditioning on p.Arg90His.
SLE, systemic lupus erythematosus; SS, Sjogren’s Syndrome; RA, rheumatoid arthritis
Association analyses were conducted in subjects with the 4:2 ratio of ΔGT/GTGT.