Table 1.

Association of SNPs in the GTF2IRD1-GTF2I-NCF1 region with autoimmune diseases in different ancestral groups

Disease	Dataset	Subject		rs73366469 (C/Ta)					rs117026326 (T/Ca)					p.Arg90His (A/Ga)				p.Ser99Gly (G/Aa)
				MAFb (%)		P	OR	Pc	MAFb (%)		P	OR	Pc	MAFb (%)		P	OR	MAFb (%)		P	OR	Pc
		Case	Control	Case	Control				Case	Control				Case	Control			Case	Control
SLE	AfrAm*	474	315	18.5	19.5	0.66	0.94		0.43	0.0	1.00			15.7	8.3	2.9×10−5	2.02	40.1	39.4	0.78	1.03
SLE	Chinese-1	436	586	29.7	13.9	1.7×10−14	2.66	0.57	28.1	11.4	1.8×10−17	3.18	0.27	38.1	15.6	2.6×10−23	3.35	43.2	26.8	1.6×10−13	2.22	0.70
SLE	Chinese-2	746	1034	30.0	15.2	6.5×10−22	2.48	0.046	27.1	11.9	2.3×10−24	2.82	0.093	41.6	16.7	1.5×10−41	3.27	46.5	28.2	1.6×10−22	2.13	0.21
SLE	Meta-Chinese	1182	1620			9.2×10−35	2.55				4.4×10−40	2.94				4.2×10−63	3.30			2.1×10−34	2.16
SLE	Korean*	611	685						30.0	11.4	3.3×10−27	3.25	0.18	46.6	18.1	2.6×10−43	3.82	52.4	30.5	3.2×10−26	2.47	0.052
SLE	Meta-Asians	1793	2305								2.0×10−65	3.05				3.1×10−104	3.47			1.5×10−58	2.26
SLE	EurAm-1*	612	485	10.8	8.5	0.036	1.37	0.64	2.4	0.72	6.4×10−3	3.25	0.59	5.5	2.1	9.5×10−5	2.83	17.8	13.0	3.9×10−3	1.44	0.12
SLE	EurAm-2*	736	446	11.9	8.5	0.012	1.46	0.25	2.4	0.67	6.1×10−3	3.51	0.29	6.0	2.4	5.0×10−4	2.42	18.6	13.1	5.5×10−4	1.53	0.057
SLE	Meta-EurAm	1348	931			1.1×10−3	1.42				1.1×10−4	3.37				1.9×10−7	2.61			7.3×10−6	1.49
SS	Chinese-SS	449	469						26.2	14.7	4.6×10−9	2.03	0.29	37.8	18.3	7.2×10−17	2.45	41.5	29.1	9.7×10−8	1.68	0.017
SS	EurAm-SS*	302	931						2.0	0.70	7.3×10−3	3.12	0.36	4.8	2.2	9.7×10−4	2.35	15.4	13.1	0.20	1.19	0.93
RA	Korean-RA	836	685											26.6	18.1	2.5×10−8	1.65	35.2	30.5	2.0×10−3	1.27	0.94

^aminor/major allele,

^bminor allele frequency,

^cP value after conditioning on p.Arg90His.

SLE, systemic lupus erythematosus; SS, Sjogren’s Syndrome; RA, rheumatoid arthritis

^*Association analyses were conducted in subjects with the 4:2 ratio of ΔGT/GTGT.