Table 3. Hazard ratios and 95% confidence intervals for prediabetes development according to percent changes in serum albumin level in subjects without obesity or insulin resistance.

Serum albumin change (per 1%)
	aAbdominal obesity (-) (n = 6,725)	p value	BMI < 23 (n = 5,431)	p value	HOMA-IR < 2.5 (n = 5,504)	p value
Crude	0.931 (0.926–0.937)	< 0.001	0.933 (0.926–0.939)	< 0.001	0.930 (0.924–0.936)	< 0.001
Multivariate 1	0.932 (0.927–0.938)	< 0.001	0.934 (0.928–0.941)	< 0.001	0.932 (0.926–0.938)	< 0.001
Multivariate 2	0.939 (0.934–0.945)	< 0.001	0.942 (0.936–0.949)	< 0.001	0.939 (0.933–0.945)	< 0.001
Multivariate 3	0.939 (0.933–0.945)	< 0.001	0.942 (0.936–0.949)	< 0.001	0.939 (0.933–0.945)	< 0.001
Multivariate 4	0.938 (0.933–0.944)	< 0.001	0.942 (0.936–0.949)	< 0.001	0.939 (0.932–0.945)	< 0.001
Multivariate 5	0.935 (0.928–0.942)	< 0.001	0.940 (0.932–0.948)	< 0.001	0.939 (0.933–0.945)	< 0.001

^aAbdominal obesity was defined as waist circumference ≥ 90 cm for men and ≥ 80 cm for women.

Data are expressed as hazard ratio (95% confidence interval). Model 1: adjusted for age, gender, and BMI. Model 2: adjusted for Model 1 plus fasting plasma glucose and HbA1c. Model 3: adjusted for Model 2 plus ALT, TG, LDL-C, HDL-C, eGFR, hypertension and smoking status. Model 4: adjusted for Model 3 plus logCRP (n = 9,789). Model 5: adjusted for Model 4 plus HOMA-IR (n = 6,222).