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. 2017 Apr 7;13(4):e1005481. doi: 10.1371/journal.pcbi.1005481

Table 1. Common dose–response functions and selected properties.

Equations give a probability of infection f(x) (response) for a number of pathogens x (dose). Parameter π = f′(0) for the functions with finite, non-zero slope at the origin. Some functions have been given non-standard parameterizations in order facilitate comparison between functions. In particular, the beta–Poisson functions are often parameterized in terms of α = πβ and N50 = β(21/α − 1). Some functions are known by different names with different parameterizations. Hill-n is called log-logistic when written in terms of β = −n and α = 1/π, and log-normal is called log-probit when written in terms of β0 = −μ/σ and β1 = 1/σ.

Model Equation f(x) Single-hit Low-dose lineara Scalable Concave
Linear {πxx1π1x>π No Yes Yes Yes
Exponential 1 − eπx Yes Yes Yes Yes
Exact beta–Poissonb 1 − 1F1(πβ, β(π + 1), − x) Yes Yes No Yes
Approximate beta–Poisson 1-(1+xβ)-πβ Yesc Yes Yes Yes
Hill-1 x1π+x Yesc Yes Yes Yes
Hill-n xn(1π)n+xn No No Yes Dependsd
Log-normale Φ(lnx-μσ) No No Yes No
Weibull 1 − e−(πx)n No No Yes Dependsd

a: Finite, non-zero low-dose linear.

b: 1F1(a, b, x) is the confluent hypergeometric function of the first kind.

c: With negative-binomial rather than Poisson distribution of organisms; see text.

d: Depends on the value of the parameters. Both Hill-n and Weibull are concave for n ≤ 1.

e: Writing the log-normal function in integral form demonstrates that it is well-defined at x = 0.