Table 1. Common dose–response functions and selected properties.
Equations give a probability of infection f(x) (response) for a number of pathogens x (dose). Parameter π = f′(0) for the functions with finite, non-zero slope at the origin. Some functions have been given non-standard parameterizations in order facilitate comparison between functions. In particular, the beta–Poisson functions are often parameterized in terms of α = πβ and N50 = β(21/α − 1). Some functions are known by different names with different parameterizations. Hill-n is called log-logistic when written in terms of β = −n and α = 1/π, and log-normal is called log-probit when written in terms of β0 = −μ/σ and β1 = 1/σ.
Model | Equation f(x) | Single-hit | Low-dose lineara | Scalable | Concave |
---|---|---|---|---|---|
Linear | No | Yes | Yes | Yes | |
Exponential | 1 − e−πx | Yes | Yes | Yes | Yes |
Exact beta–Poissonb | 1 − 1F1(πβ, β(π + 1), − x) | Yes | Yes | No | Yes |
Approximate beta–Poisson | Yesc | Yes | Yes | Yes | |
Hill-1 | Yesc | Yes | Yes | Yes | |
Hill-n | No | No | Yes | Dependsd | |
Log-normale | No | No | Yes | No | |
Weibull | 1 − e−(πx)n | No | No | Yes | Dependsd |
a: Finite, non-zero low-dose linear.
b: 1F1(a, b, x) is the confluent hypergeometric function of the first kind.
c: With negative-binomial rather than Poisson distribution of organisms; see text.
d: Depends on the value of the parameters. Both Hill-n and Weibull are concave for n ≤ 1.
e: Writing the log-normal function in integral form demonstrates that it is well-defined at x = 0.