Fig. 3.

Effects of neighboring TSG(s) on the propensity of oncogenes to copy number alterations and nonsynonymous point mutations. (A) Oncogenes with a neighboring TSG (i.e., within a 1.46-Mbp radius; Group I oncogenes) were amplified to a lesser extent in TCGA-sequenced cancer types than those without (Group II oncogenes). Wilcoxon test was used to compare the GISTIC scores of two groups of oncogenes. *P < 0.05; **P < 0.01; ***P < 0.001 significantly different between groups. (B) Group I and Group II oncogenes exhibited similar rates of nonsynonymous point mutations in TCGA-sequenced cancer types.