Change from baseline (Note: For vital sign changes, baseline refers to the antecedent study baseline [if enrollment gap was <30 days from antecedent study completion] or the last value collected at or before the extension study baseline visit [if enrollment gap was ≥30 days from antecedent study completion]). For weight changes, baseline refers to the antecedent study baseline [if the enrollment gap was <30 days from antecedent study completion] or the last value collected at or before the extension study baseline [if the enrollment gap was ≥30 days from antecedent study completion] in (A) SBP and DBP, (B) pulse, and (C) body weight by treatment week, safety analysis set. F/U indicates follow-up. *SBP baseline, 116.14 (10.309) mm Hg (n = 599). †DBP baseline, 76.32 (7.725) mm Hg (n = 599). ‡Pulse baseline, 72.18 (9.637) beats per minute (n = 599). §For change in body weight and percentage change in body weight, n = 529 at week 12, n = 516 at week 16, n = 387 at week 44, and n = 458 at follow-up.