Table 1.
Incidence of HCA, HCC, and CC (cholangiocarcinoma) in Alb-Cre::Mad2l1::Trp53 mice. The HCA/CC column describes the number of mice with HCC that also have HCA or CC.
| 4–8 (Mo) | 8–12 (Mo) | 12–16 (Mo) | 16–20 (Mo) | 20–24 (Mo) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCA | HCC | HCA | CC | HCA | HCC | HCA | HCA | HCC | HCA | HCA | HCC | HCA | HCA | HCC | HCA | CC | |
| CC | CC | CC | CC | CC | |||||||||||||
| Mad2l1f/f: :Trp53+/+ | 2/17 | 0/17 | / | 0/17 | 8/14 | 1/14 | / | 1/4 | 2/4 | / | 2/13 | 6/13 | 5/6 | 19/34 | 5/34 | 3/5 | 0/34 |
| / | / | / | |||||||||||||||
| Mad2l1f/f: :Trp53f/f | 2/14 | 5/14 | 2/5 | 1/14 | 1/27 | 22/27 | 8/22 | 0/9 | 9/9 | 4/9 | 0/15 | 13/15 | 6/13 | 0/4 | 4/4 | 1/4 | 0/4 |
| 2/5 | / | 1/9 | 2/4 | ||||||||||||||
| Mad2l1f/f: :Trp53f/+ | 2/12 | 2/12 | 1/2 | 1/12 | 2/17 | 3/17 | 1/3 | 0/8 | 5/8 | 3/5 | 11/25 | 12/25 | 6/12 | 3/10 | 5/10 | 3/5 | 0/10 |
| / | 2/3 | 2/12 | |||||||||||||||
| Mad2l1f/+: :Trp53f/f | 0/10 | 0/10 | / | 0/10 | 0/10 | 0/10 | / | 0/1 | 0/1 | / | 1/11 | 2/11 | / | 2/13 | 4/13 | 1/4 | 1/13 |
| / | / | / | 1/2 | 2/4 | |||||||||||||
| Mad2l1f/+: :Trp53f/+ | 0/13 | 0/13 | / | 0/13 | 0/7 | 0/7 | / | 0/3 | 0/3 | / | 2/8 | 0/8 | / | 0/8 | 2/8 | / | 0/8 |
| / | / | / | / | / | |||||||||||||
| Mad2l1f/+: :Trp53+/+ | 0/15 | 0/15 | / | 0/15 | 0/6 | 0/6 | / | 0/3 | 0/3 | / | 1/8 | 0/8 | / | 2/13 | 2/13 | 1/2 | 0/13 |
| / | / | / | / | ||||||||||||||
| Mad2l1+/+: :Trp53f/f | 0/2 | 0/2 | / | 0/2 | 0/4 | 0/4 | / | 0/2 | 1/2 | 1/2 | 3/10 | 2/10 | 1/2 | 0/1 | 1/1 | / | 0/1 |
| / | / | 1/2 | / | / | |||||||||||||
| Mad2l1+/+: :Trp53f/+ | NA | NA | NA | NA | NA | 0/2 | 0/2 | / | 0/4 | 0/4 | / | 0/1 | 0/1 | / | 0/1 | ||
| Mad2l1+/+: :Trp53+/+ | 0/3 | 0/3 | / | 0/3 | 0/2 | 0/2 | / | 0/3 | 0/3 | / | 0/3 | 0/3 | / | 0/4 | 0/4 | / | 0/4 |
| Alb-cre– | 0/6 | 0/6 | / | 0/6 | 0/9 | 0/9 | / | 1/7 | 0/7 | / | NA | NA | NA | NA | NA | ||