Figure 6. HDAC inhibition antagonized rescue of EedCKO by EED re-expression.
(A) Schematic of the experimental design. (B) Heart function was measured by echocardiography as fraction shortening (FS%) in 2-month-old EedCKO or Het mice that received the indicated treatments. Two of five EedCKO + EED + SAHA mice died prior to the study endpoint and were not available for echocardiography. (C) qRTPCR measurement of five selected genes that were aberrantly expressed in EedCKO hearts. P-value by Student’s t-test. *p<0.05; **p<0.01; NS, not significant.