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. 2017 Feb 11;8(13):20602–20611. doi: 10.18632/oncotarget.15292

Figure 4. The effects of caffeine on the ZP hardening and fertilization by ICSI during oocyte aging.

Figure 4

A. Changes in chymotrypsin digestion time of ZP (T50 is the time at which 50% of the ZPs per group were completely digested) of fresh oocytes, caffeine-treated oocytes and oocytes aged in vitro. B. The fertilization of fresh oocytes, caffeine treated oocytes and oocytes aged in vitro after Intracytoplasmic sperm injection (ICSI). Abbreviations used in this and all subsequent figures: CA, caffeine treated; IVA, in vitro aging. a-c: Values without a common letter in their superscripts differ significantly (P < 0.05).