Table 1. Candidate genes and candidate epistatic variants.

Gene	ID	Effect	Proposed Interaction	Reference
APOA1	rs670	Deleterious	Buffered	Garasto et al., 2003 [45]
APOE	APOEε4	Deleterious	APOEε4 buffered by HP1/1	Napolioni et al., 2011 [44]
HFE	rs1800562	Deleterious	HFE T allele buffered	Tan et al., 2003 [24]
KL	rs9536314	Deleterious	KL het buffered	Bergman et al., 2007 [7]
LPA(1)	rs1853021	Deleterious	LPA het buffered by CETP VV	Bergman et al., 2007 [7]
LPA(2)	rs3798220	Deleterious	Risk for coronary disease	Clarke et al., 2009 [22]
LPA(3)	rs10455872	Deleterious	Risk for coronary disease	Clarke et al., 2009 [22]
MTTP	rs2866164	Deleterious	MTTP CC buffered by APOC3 CC, CETP VV, ADIPOQ del/del	Huffman et al., 2012 [46]
PON1	rs662	Deleterious	PON1 het buffered	Bonafè et al., 2002 [47]
ADIPOQ	rs56354395	Protective	ADIPOQ del/del buffers MTTP CC	Atzmon et al., 2008 [27]
APOC3	rs595049 (LD with rs2542052)	Protective	APOC3 CC buffers MTTP CC	Atzmon et al., 2006 [48]
CETP	rs5882	Protective	CETP VV buffers MTTP CC, LPA(1) het	Barzilai et al., 2003 [29]
CRYL1	rs7989332	Protective	AD-associated with KHDRBS2	Gusareva et al., 2014 [15]
FOXO1	rs2701858	Protective	Joint effect with FOXO3(1) for longevity	Tan et al., 2013 [49]
FOXO3(1)	rs9486902	Protective	Joint effect with FOXO1 for longevity	Tan et al., 2013 [49]
FOXO3(2)	rs2802292	Protective	FOXO3 GG buffering	Willcox et al., 2008 [20]
HP	rs72294371	Protective	HP1/1 buffers APOEε4	Napolioni et al., 2011 [44]
KHDRBS2	rs6455128	Protective	AD-associated with CRYL1	Gusareva et al., 2014 [15]

Effect indicates whether the variant was considered be deleterious or protective in the original literature report. Het = heterozygous, AD = Alzheimer's disease.