Table 3. Odds ratios and 95% confidence intervals for the association between variants in APOE and HP and healthy aging.
| Variant | Model | Super-Seniors | Controls | Genotype | Odds ratio (95% CI) | p value |
|---|---|---|---|---|---|---|
| HP rs72294371 | Dominant | 99 | 63 | 1/1 | 1 | 0.010 |
| 325 | 325 | 1/2 or 2/2 | 0.63(0.44-0.90) | (df=1) | ||
| Additive | 99 | 63 | 1/1 | 1 | 0.056 (df=1) | |
| 199 | 202 | 1/2 | 0.62 (0.43-0.90) | |||
| 126 | 123 | 2/2 | 0.64 (0.42-0.96) | |||
| APOE haplotype | ε4 Dominant | 365 88 |
293 119 |
Non- ε4 carrier ε4 carrier |
1 0.59 (0.43-0.81) |
0.0010 (df=1) |
| Overall | 283 | 248 | ε3/ε3 | 1 | 0.00017 (df=5) | |
| 18 | 3 | ε2/ε2 | 5.33 (1.55-18.34) | |||
| 64 | 42 | ε2/ε3 | 1.32 (0.86-2.02) | |||
| 77 | 94 | ε3/ε4 | 0.71 (0.50-1.01) | |||
| 7 | 15 | ε2/ε4 | 0.40 (0.16-1.00) | |||
| 4 | 10 | ε4/ε4 | 0.35 (0.11-1.12) |