Figure 5. Penetration of Listeria into pancreatic tumor, metastases and healthy tissues of KPC model.

KPC mice received one dose of 10⁷ CFU of Listeria ip. Two days later, the number of CFU of Listeria was measured in all tissues, including the pancreatic tumor and metastases. (A) KPC mouse with late stage pancreatic cancer. (B) KPC mouse with early stage pancreatic cancer (tumor and metastases not detectable yet). Confocal microscopy pictures show the pancreas with or without Listeria of KPC mice with or without pancreatic cancer, respectively.