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. 2017 Feb 15;8(13):20865–20880. doi: 10.18632/oncotarget.15348

Figure 10. Platelets increase ovarian cancer sphere formation, an effect inhibited by metformin in the UCI101 cell line.

Figure 10

(A) Spheres images (10X) of UCI101 cell line and SKOV3 cell line. (B) Quantification of average of sphere number and sphere diameter at day 2. *P < 0.05 respect to control, #P < 0.05 respect to Platelets. ANOVA with Tukey post-test. (C) Spheres images (10X) and quantification of average of sphere number and diameter at day 2 of primary cultures of ovarian cancer cells of patient 3, 4 and 5. (D) Standard deviation is shown. Only in Patient 5 did metformin not reduce the increase in sphere formation induced by platelets.