Table 2. Effects of G1 administration on systemic hemodynamic variables in anesthetized rats in vivo.
| Group | Steady state | LAD reperfusion | |
|---|---|---|---|
| 1-2 min | 60 min | ||
| SAP, mm Hg | |||
| Control | 86 ± 3 | 85 ± 2 | 86 ± 3 |
| G1-0.4 | 82 ± 2 | 63 ± 2 a b | 81 ± 4 |
| G1-0.7 | 84 ± 2 | 64 ± 2 a b | 83 ± 2 |
| G1-1.3 | 89 ± 3 | 69 ± 3 a b | 87 ± 2 |
| HR, beats /min | |||
| Control | 334± 5 | 331 ± 4 | 332 ± 4 |
| G1-0.4 | 338± 6 | 314 ± 7 a b | 337 ± 7 |
| G1-0.7 | 329 ± 5 | 306 ± 6 a b | 330 ± 5 |
| G1-1.3 | 332± 4 | 246 ± 4 a b c d | 327 ± 6 |
G1 was administrated by i.v. bolus injection at the onset of reperfusion at doses of 0.4; 0.7 or 1.3 μmol/kg (groups G1-0.4, G1-0.7 or G1-1.3, respectively). An equal volume of saline was injected in control. Values are expressed as mean ± SEM for 12 experiments. Significant difference (P<0.05) from: a steady state; b control; c G1-0.4; d G1-0.7.