Table 4. Mean consumption of selected foods, alcohol and tobacco for the CA6 rs2274333 genotype in all subjects and colorectal cancer cases and controls (mean ± standard deviation).
| CA6 rs2274333 | Energy (kcal/day) | Vegetables (g/day) | Fruits (g/day) | Fiber (g/day) | Fat-food (g/day) | Sweets (g/day) | Alcohola (g/day) | Tobaccoa (cigarettes/day) | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| All | Cruciferous | Dark green | All | Citrus | |||||||
| All subjects (n = 2042) | |||||||||||
| AA (n = 353) | 2031.8 ± 661.5 | 374.5 ± 198.8 | 175.6 ± 109.0 | 37.5 ± 36.8 | 190.4 ± 221.5 | 43.9 ± 62.7 | 19.2 ± 6.5 | 4.6 ± 5.0 | 23.7 ± 30.2 | 23.4 ± 29.3 | 17.6 ± 10.7 |
| GA (n = 957) | 1965.2 ± 638.2 | 376.9 ± 193.0 | 179.1 ± 114.4 | 39.5 ± 34.3 | 183.8 ± 190.2 | 37.6 ± 52.0 | 19.5 ± 6.5 | 4.7 ± 4.6 | 26.1 ± 38.6 | 21.9 ± 30.0 | 16.1 ± 8.7 |
| GG (n = 732) | 1957.4 ± 617.7 | 372.3 ± 183.8 | 177.8 ± 104.4 | 37.8 ± 34.7 | 186.3 ± 179.5 | 40.0 ± 54.1 | 19.5 ± 6.6 | 4.8 ± 4.6 | 26.8 ± 45.1 | 22.4 ± 30.2 | 16.9 ± 9.3 |
| pcrudeb | 0.199 | 0.917 | 0.820 | 0.226 | 0.399 | 0.453 | 0.673 | 0.687 | 0.789 | 0.722 | 0.174 |
| padjustedc | 0.185 | 0.959 | 0.256 | 0.487 | 0.158 | 0.256 | 0.924 | 0.690 | 0.716 | 0.989 | 0.347 |
| pttestd | 0.073 | 0.815 | 0.555 | 0.149 | 0.521 | 0.429 | 0.381 | 0.406 | 0.532 | 0.493 | 0.143 |
| Controls (n = 1,361) | |||||||||||
| AA (n = 211) | 1828.9 ± 575.1 | 400.0 ± 222.5 | 183.9 ± 121.0 | 41.5 ± 41.3 | 210.6 ± 260.4 | 46.1 ± 71.6 | 20.3 ± 7.1 | 4.6 ± 5.1 | 22.6 ± 28.2 | 16.5 ± 21.2 | 15.1 ± 6.8 |
| GA (n = 658) | 1843.7 ± 614.3 | 393.5 ± 207.3 | 185.5 ± 122.8 | 43.5 ± 37.2 | 195.1 ± 199.5 | 38.6 ± 52.0 | 20.4 ± 6.8 | 4.4 ± 4.6 | 24.5 ± 35.2 | 16.8 ± 22.0 | 15.2 ± 8.2 |
| GG (n = 492) | 1838.7 ± 586.3 | 387.7 ± 204.5 | 181.2 ± 113.5 | 40.9 ± 39.8 | 204.3 ± 199.4 | 42.2 ± 60.7 | 20.4 ± 7.3 | 4.6 ± 4.5 | 27.4 ± 50.5 | 18.3 ± 22.1 | 16.1 ± 8.6 |
| pcrude | 0.998 | 0.750 | 0.844 | 0.268 | 0.311 | 0.685 | 0.963 | 0.622 | 0.847 | 0.418 | 0.411 |
| padjusted | 0.797 | 0.662 | 0.390 | 0.416 | 0.121 | 0.380 | 0.899 | 0.669 | 0.893 | 0.388 | 0.487 |
| pttest | 0.953 | 0.607 | 0.879 | 0.440 | 0.674 | 0.893 | 0.783 | 0.911 | 0.624 | 0.645 | 0.811 |
| Cases (n = 681) | |||||||||||
| AA (n = 142) | 2333.1 ± 668.4 | 336.6 ± 150.1 | 163.4 ± 87.3 | 31.6 ± 27.8 | 160.4 ± 141.4 | 40.3 ± 45.3 | 17.7 ± 5.2 | 4.7 ± 4.8 | 25.4 ± 32.9 | 33.6 ± 36.2 | 21.5 ± 14.2 |
| GA (n = 299) | 2232.6 ± 608.7 | 340.3 ± 151.0 | 164.9 ± 91.9 | 30.8 ± 24.9 | 159.1 ± 166.0 | 35.4 ± 52.1 | 17.8 ± 5.3 | 5.3 ± 4.5 | 29.5 ± 45.1 | 34.0 ± 41.0 | 18.0 ± 9.4 |
| GG (n = 240) | 2200.7 ± 610.4 | 340.9 ± 126.1 | 170.8 ± 82.4 | 31.2 ± 19.1 | 149.3 ± 121.8 | 35.3 ± 35.5 | 17.7 ± 4.5 | 5.0 ± 4.8 | 25.7 ± 31.2 | 31.2 ± 41.4 | 18.7 ± 10.5 |
| pcrude | 0.183 | 0.754 | 0.333 | 0.488 | 0.977 | 0.481 | 0.977 | 0.212 | 0.661 | 0.404 | 0.265 |
| padjusted | 0.061 | 0.810 | 0.377 | 0.617 | 0.904 | 0.377 | 0.910 | 0.328 | 0.800 | 0.555 | 0.166 |
| pttest | 0.095 | 0.541 | 0.515 | 0.427 | 0.840 | 0.267 | 0.851 | 0.155 | 0.377 | 0.450 | 0.125 |
aThe mean consumption was estimated among current/former drinkers and smokers.
bP-values for crude generalized linear models comparing the intake of selected foods, alcohol and tobacco among groups.
cP-values for generalized linear models adjusted for sex, age, body mass index, smoking, alcohol drinking, regular exercise, family history of colorectal cancer, marital status, education level and household income as appropriate.
dP-values from Student’s t-tests comparing between genotypes of the dominant model (AA versus GG+GA).