Table 4. Univariate and multivariate Cox Regression analysis between OS and univariate Cox Regression analysis between PFS, RASSF1A methylation status of primary tumor samples and clinicopathological features of the patients (group B).

Univariate Cox Regression analysis (Dependent Variable: OS)
	P-value	HR (hazard ratio)	95.0% CI for HR
			Lower	Upper
RASSF1A methylation (real-time MSP)	0.166	1.896	0.767	4.688
RASSF1A methylation (MS-HRMA)	0.030	2.761	1.102	6.915
Age	0.844	0.913	0.370	2.254
Tumor grade (G)	0.744	0.860	0.348	2.126
Regional lymph nodes (pN)	0.432	0.640	0.210	1.948
Distant metastasis (M)	0.784	1.189	0.345	4.096
Platinum resistance	0.019	3.752	1.245	11.306
Tumor rest	0.758	0.859	0.326	2.263
Multivariate Cox Regression analysis (Dependent Variable: OS)
RASSF1A methylation (MS-HRMA)	0.253	1.818	0.653	5.064
Platinum resistance	0.024	3.588	1.185	10.863
Univariate Cox Regression analysis (Dependent Variable: PFS)
	P-value	HR (hazard ratio)	95.0% CI for HR
			Lower	Upper
RASSF1A methylation (real-time MSP)	0.943	1.029	0.468	2.264
RASSF1A methylation (MS-HRMA)	0.682	1.179	0.536	2.596
Age	0.827	1.093	0.494	2.416
Tumor grade (G)	0.401	1.405	0.636	3.106
Regional lymph nodes (pN)	0.599	0.773	0.296	2.018
Distant metastasis (M)	0.797	0.851	0.249	2.909
Platinum resistance	0.403	-	-	-
Tumor rest	0.597	1.244	0.554	2.792