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A. and B. Plasma and brain concentration-time profile of DS7423 following a single PO administration (6 mg/kg) to nude mice. C. Western blot of mouse brains probed with antibodies against pAkt (Ser473) and pS6 (Ser235/236) in a time profile similar to that shown in A and B. Results are presented as the mean ± SE of six animals in each group.
