Table 4. Univariate and multivariate Cox proportional hazards analysis of KLF3 expression on overall survival for patients with colorectal cancer in the validation cohort.
| Factor | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Gender | 0.925(0.549-1.558) | 0.769 | ||
| Age | 1.001(0.981-1.021) | 0.928 | ||
| T category | 2.095(1.380-3.180) | 0.001 | 1.233(0.777-1.956) | 0.374 |
| N stage | 3.751(2.646-5.318) | <0.001 | 3.000(2.360-4.477) | 0.020 |
| Grade | 6.102(3.568-10.435) | <0.001 | 4.466(2.343-8.515) | <0.001 |
| Lymphovascular invasion | 3.852(2.243-6.616) | <0.001 | 3.454(1.500-7.955) | 0.004 |
| Perineural invasion | 3.385(1.815-6.312) | <0.001 | 1.628(0.628-1.343) | 0.140 |
| KLF3 | 0.378(0.214-0.667) | 0.001 | 0.628(0.342-0.922) | 0.035 |
*Abbreviations: CI, confidence interval; HR, hazard ratio.
**Bold type indicates statistical significance.