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. 2017 Feb 28;8(13):21994–22002. doi: 10.18632/oncotarget.15777

Figure 3. Association between DNA methylation ITH level and patient characteristics.

Figure 3

Boxplots show the methylation ITH as the Euclidean distance between different tumor regions within each tumor. Solid horizontal line within each box is the median; solid box shows the 25 and 75 percentile, and caps show the 5 and 95 percentile. (a) The association of methylation ITH and tumor size - average Euclidean distance 35.64 (> 3 cm, median) versus 27.24 (<= 3 cm). (b) The association of methylation ITH with advanced age - average Euclidean distance 34.95 (above 65) versus 28.06 (below 65). (c) The association of methylation ITH with recurrence status - average Euclidean distance 35.65 (relapsed patients) versus 29.03 (patients without relapsed). Matched normal lung tissues were excluded in this analysis. All p-values are from Student’s t-test.