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. 2017 Feb 28;8(13):22003–22013. doi: 10.18632/oncotarget.15781

Figure 8. Schema of mitochondrial apoptosis pathway in T-47D-CSCs response to cisplatin and miR-519d.

Figure 8

Combination with miR-519d and cisplatin induces the damage of mitochondria, resulting in the release of cytochrome C and Smac/DIABLO. Subsequently, caspases are activated and apoptosis is occurred.