Table 1. The clinical and pathologic features of 18 HVPTC cases.
| Case | Age/sex | Size (cm) | Multifocal | Percentage of hobnail features | Percentage of other variants | LVI | ETE | LN METS | Postsurgical I131treatment | Local recurrence | Distant METS | pTNM | Follow up (months) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 32/M | 1.5 | No | 40% | 60%CPTC | No | No | Yes(2/2) | No | No | No | PT1bN1M0 | not available |
| 2 | 76/F | 5 | No | 50% | 20%CPTC 10%CCVPTC 10%TCVPTC | Yes | Yes | Not available | No | Yes | Yes(Lung) | PT3NXM1 | 17m, DOD |
| 3 | 31/M | 1.8 | No | 100% | No | No | Yes(9/27) | Yes | No | No | PT1bN1M0 | 100m, NED | |
| 4 | 51/F | 2.5 | No | 80% | 10%CPTC 10%DSVPTC | No | Yes | N | Yes | No | No | PT3N0M0 | 95m, NED |
| 5 | 25/F | 2.2 | No | 50% | 30%CCVPTC 20%CPTC | No | No | N | No | No | No | PT2N0M0 | 101, NED |
| 6 | 33/F | 1.5 | No | 80% | 20%CPTC | No | No | N | No | No | No | PT1bN0M0 | 92m, NED |
| 7 | 49/M | 1.6 | No | 60% | 40%CPTC | No | Yes | N | Yes | No | No | PT3N0M0 | 89m, NED |
| 8 | 56/F | 3.3 | No | 100% | No | No | Yes(2/7) | Yes | No | No | PT2N1M0 | 82m, NED | |
| 9 | 38/F | 2.5 | No | 60% | 40%CPTC | No | Yes | N | No | No | No | PT3N0M0 | 74m, NED |
| 10 | 25/F | 2 | No | 30% | 70%CPTC | No | Yes | N | No | No | No | PT3N0M0 | 82m, NED |
| 11 | 27/F | 3.1 | No | 80% | 20%CPTC | No | No | N | No | No | No | PT2N0M0 | not available |
| 12 | 45/F | 1.3 | Yes | 40% | 40%CPTC 20%CCVPTC | No | No | Yes(4/4) | No | No | No | PT1bN1M0 | 73m, NED |
| 13 | 78/F | 2.5 | Yes | 40% | 60%CPTC | No | No | Yes(4/22) | No | No | No | PT2N1M0 | 74m, NED |
| 14 | 27/M | 3 | No | 80% | 20%CPTC | No | No | Yes(3/9) | No | No | Yes(Bone) | PT2N1M1 | 53m,AWD |
| 15 | 65/F | 5 | No | 40% | 50%CPTC 10%TCVPTC | Yes | Yes | Yes(2/7) | No | No | No | PT3N1M0 | 12m,DOC |
| 16 | 23/M | 1.8 | No | 90% | 10% CPTC | No | No | Yes(1/4) | Yes | No | No | PT1bN1M0 | 68m, NED |
| 17 | 32/F | 1 | No | 40% | 30%CPTC 30%CCVPTC | No | No | Yes(3/12) | Yes | No | No | PT1aN1M0 | 68m, NED |
| 18 | 40/F | 4 | Yes | 60% | 20%CPTC, 20% FTC | No | No | Yes(3/22) | No | No | No | PT2N1M0 | 70m, NED |
F: female, M: male, LVI: lymphovascular invasion, ETE: extrathyroidal extension, LN: lymph node, METS: metastases, AWD: alive with disease, DOD: died of disease, DOC: died of other causes, NED: no evidence of disease, CPTC: conventional PTC, CCVPTC: Columnar cell-variant papillary thyroid carcinoma, TCVPTC: Tall cell-variant papillary thyroid carcinoma; DSVPTC: Diffuse sclerosing-variant PTC, FVPTC: follicular-variant papillary thyroid cancer