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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: J Neural Transm (Vienna). 2017 Jan 23;124(5):655–667. doi: 10.1007/s00702-017-1680-4

Figure 3.

Figure 3

Dopamine type 1-like receptor (D1R) binding following chronic oral methylphenidate treatment (A&C) and abstinence (AB) (B&D). (A) High dose (HD MP) treated rats had increased D1R-like binding in the olfactory tubercle (OT), middle dorsolateral caudate putamen (mid dl CPu), middle dorsomedial caudate putamen (mid dm CPu), middle ventromedial caudate putamen (mid vm CPu), and dorsal tail of the caudate putamen (d CPu tail) compared to water treated rats, and in the OT, vm CPu, and d CPu tail compared to LD MP treated rats (p≤0.01 for all). *HD MP vs. water, ∧HD MP vs. LD MP. (B) There were no significant differences in D1R-like binding between treatment groups in rats euthanized after an abstinence period. (C&D) Autoradiographic images of dopamine type 1-like receptor binding with [3H] SCH23390. Images represent brain sections from rats treated with water, low dose methylphenidate (LD MP), and high dose methylphenidate (HD MP) and euthanized immediately following treatment (C) or after an abstinence (AB) period (D). Measures on left show approximate distance from Bregma.