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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: J Neural Transm (Vienna). 2017 Jan 23;124(5):655–667. doi: 10.1007/s00702-017-1680-4

Figure 4.

Figure 4

Dopamine type 2-like receptor (D1R) binding following chronic oral methylphenidate treatment (A&C) and abstinence (AB) (B&D). There were no significant differences in D2R-like binding between treatment groups in rats euthanized immediately following abstinence or after an abstinence period. (C&D) Autoradiographic images of dopamine type 2-like receptor binding with [3H] Spiperone. Images represent brain sections from rats treated with water, low dose methylphenidate (LD MP), and high dose methylphenidate (HD MP) and euthanized immediately following treatment (C) or after an abstinence (AB) period (D). Measures on left show approximate distance from Bregma.