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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Exp Neurol. 2017 Feb 16;292:35–45. doi: 10.1016/j.expneurol.2017.02.012

Figure 7. FNCS1 and α4 integrin (CD49d) expression in CIDP patient nerve biopsies.

Figure 7

Digital indirect fluorescent photomicrographs of an axial section from the sural nerve biopsy of an untreated CIDP patient demonstrates a cluster of round mononuclear cells (a: DAPI, blue) associated with a FNCS1 expressing (b: red) endoneurial microvessel (c: UEA-1, green), verified by co-localization in the merged image (d: yellow). Longitudinal sural nerve biopsy sections show multiple small foci of endoneurial CD49d+ CD45+ leukocytes at lower magnification (e–h). Higher magnification photomicrographs from different untreated CIDP patients show clusters of endoneurial CD49d+ CD45+ leukocytes (i and j: white arrows). Extravasating and perivascular CD49d+ CD45+ leukocytes are also seen (k and l). CD49d+ CD45+ leukocytes were rarely seen within the endoneurium of normal control sural nerve biopsies (m: white arrow). EMV= endoneurial microvessel. Scale bars = 50 μm (a–d), 100 μm (e–h), 40 μm (i, j and m) and 20 μm (k and l)