Table 1.

Recent Mouse models of pulmonary hypertension published since 2012

Mouse strain	Genetic modification	RVSP, mmHg		RV/LV+S		Histology		Ref
		Normoxia	Hypoxia	Normoxia	Hypoxia	Normoxia	Hypoxia
C57BL6/J	Prkg1−/−	43	N/A	N/A	N/A	↑Musc	N/A	Zhao(2012)
C57BL6/J	Il13 Tg	38	N/A	0.31	N/A	↑Musc	N/A	Cho(2013)
C57BL6/J	Irp1−/−	36	N/A	N/A	N/A	N/A	N/A	Ghosh (2013)
C57BL6/J	EC Smad1−/−	28	N/A	0.294	N/A	↑Musc	N/A	Han(2013)
	SMC Smad1−/−	25	N/A	0.313	N/A	↑Musc	N/A
C57BL6/J	Ccr2−/−	30	47	0.28	0.41	↑Musc	↑Musc	Yu(2013)
	Ccl2−/−	26	42	0.27	0.42	N/A	N/A
C57BL6/J	Sod1−/−	34	34	0.32	0.41	↑Musc	N/A	Ramiro-Diaz(2013)
C57BL6/J	SMC Pten−/−	30	35	0.27	0.42	↑Musc	Occlusive intima of small PA	Hortia (2013)
C57BL6/J	EC Gata6−/−	27	33	0.31	0.48	Normal	↑Musc	Ghatneka (2013)
C57BL6/J	Hif2aG536w knock in	66	N/A	0.61	N/A	↑Musc	N/A	Tan(2013)
C57BL6/J	Ucp2−/−	25(mPAP)	28(mPAP)	N/A	N/A	↑Musc	No difference	Dromparis (2013)
C57BL6/J	EC Klf4−/−	24	34	0.28	0.40	Normal	↑Musc	Shatat (2014)
C57BL6/J	Aplnr−/−	35	N/A	0.38	N/A	Occluded PV	N/A	Lathen (2014)
	EC Aplnr−/−	35	N/A	0.38	N/A	Occluded PV	N/A
	Erg−/−	50	N/A	0.48	N/A	Occluded PV	N/A
C57BL6/J	Sirt3−/−	30(mPAP)	N/A	0.33	N/A	↑Musc	N/A	Paulin (2014)
C57BL6/J	SMC Foxo1−/−	30	35	0.24	0.28	↑Musc	↑Musc	Savai (2014)
C57BL6/J	Epha2−/−	25	32(Hx) 35 (SuHx)	0.25	0.42(Hx) 0.47(Su Hx)	Normal	No difference	Rhodes (2015)
C57BL6/J	EC Fas-induced apoptosis-EFIA	29	N/A	0.27	N/A	Occlusive small PA	N/A	Goldthorp (2015)
C57BL6/J	Egln1Cdh5Cre	54	N/A	0.5	N/A	↑Musc	N/A	Kapitsino (2016)
C57BL6/J	Egln1Tie2Cre	72	N/A	0.85	N/A	↑Musc, occlusive small and large PA, plexiform lesions	N/A	Dai(2016)
C57BL6/J	EC Ampk−/−	27	38	0.2	0.37	Normal	↑Musc	Omura (2016)

Hx, hypoxia; Musc, muscularization of distal pulmonary vessels; mPAP, mean pulmonary arterial pressure; N/A, not analyzed; PA, pulmonary artery; PV, pulmonary vein; SuHx, Sugen5416/hypoxia.