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. Author manuscript; available in PMC: 2017 Apr 21.
Published in final edited form as: ACS Chem Biol. 2017 Feb 15;12(4):947–957. doi: 10.1021/acschembio.6b01074

Figure 4.

Figure 4

Cysteines involved in Fe-S clusters. (A) Schematic of the proteins involved in the Fe-S cluster biogenesis pathway, including cluster generation on the scaffold protein ISCU, proposed cluster transfer to Grx5, and delivery to target mitochondrial proteins, such as complex I and lipoyl synthase (LIAS). (B) List of all known mitochondrial Fe-S proteins, with their ligating residues depicted. Proteins are color coded to match the diagram in 4A. Cysteine residues and Fe-S clusters are highlighted in red if they were identified in the mitochondrial datasets. Detailed information on identified mitochondrial iron-sulfur proteins is presented in Supplemental Table 13.