Table 2.
Detailed demographic, behavioural and virological characteristics of participants with HCV reinfection (n=10)
Gender, age1 | HIV | Mode of primary HCV | IDU | HCV genotype | Region sequenced | Time between EOT and reinfection (weeks) | ALT | Reinfection outcome | |||
---|---|---|---|---|---|---|---|---|---|---|---|
At screening2 | During follow-up | Primary | Reinfection | EOT | Reinfection | ||||||
Confirmed reinfection
| |||||||||||
Male 29 |
No | IDU | Yes | Yes | 3a | 1a | E1/HVR1 | 18 | 21 | 53 | Spontaneous clearance |
Male 49 |
Yes | IDU | Yes | Yes | 3a/1a | 3a/1a | Core-E2 | 81 | 83 | 1135 | Persistence |
Male 36 |
No | IDU | Yes | Yes | 1a | 3a | E1/HVR1 Core-E2 |
30 | 26 | 319 | Persistence |
Male 44 |
Yes | Sexual | No | No | 2a | 1a/3a | Core-E2 | 40 | 58 | 565 | Indeterminate |
Male 50 |
Yes | Sexual | No | Yes | 1a | 1a | NS5B | 65 | 18 | 15 | Indeterminate |
Male 62 |
Yes | IDU | Yes | Yes | 3a | 1a | Core-E2 NS5B |
39 | 15 | 65 | Persistence |
Male 45 |
Yes | Sexual | No | No | 1a | 1a | Core-E2 NS5B |
18 | 29 | 54 | Persistence |
Male 41 |
Yes | IDU | Yes | Yes | 3a | 1a | Core-E2 NS5B |
9 | 23 | 910 | Persistence |
| |||||||||||
Possible reinfection
| |||||||||||
Male 35 |
No | IDU | Yes | Yes | 3a | NA3 | InnoLipa | 31 | 15 | 14 | Spontaneous clearance |
Male 46 |
Yes | Sexual | No | Yes4 | 1a | NA3 | InnoLipa | 64 | 71 | 43 | Spontaneous clearance |
Age at study enrolment
IDU within 6 months of study enrolment
Unable to sequence due to low HCV RNA at time of viral recurrence
Anabolic steroids
Abbreviations: ALT, alanine aminotransferase; EOT, end of treatment; IDU, injecting drug use1 ALT, normal range 0–30 U/L