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Flip angle scheme including a ramp-up preparation pulse and ramp-down flip back pulse (A). Simulated on-resonance magnetization evolution (B). Simulation parameters include: number of echoes = 256, T1 = 40s, T2 = 1s, TR = 3.785ms. Optimized lactate-only RF pulse with shortest duration (C), and its simulated spectral profile (D).
