Table 7.

Studies in which vitamin D levels are correlated to autoantibodies associated with Multiple sclerosis (MS)

Author	Year	Country	Subjects	Vitamin D (ng/ml)	Vitamin D effect / Autoantibodies	P valued	Reference
Mowry E.M. et al.	2011	USA	120 MSa/CIS, 20 CTRL	NR	anti-CMV, anti-EBV, HSV-1/-2	0.004 NS	[69]
Salzer J. et al.	2013	Sweden	192 MS, 384 CTRL	NR	anti-EBNA1	0.03	[72]
Décard B.F.et al.	2012	Germany	25 pre-CIS, 25 CTRLb	NR	anti-EBNA1	<0.01	[73]
Disanto G. et al.	2013	The Netherlands	15 RRMSc	NR	anti-EBNA1	0.016	[74]
Najafipoor A. et al.	2015	Iran	40 RRMS (27 vit. D suppl., 13 CTRL)	NR	anti-VCA IgG, anti-EBNA1	0.420 0.853	[75]

NR = Not reported; CIS = clinically isolated syndrome (prior to first clinical MS manifestation); CMV = cytomegalovirus; EMB = Epstein Barr Virus; HSV =

Herpes Simplex Virus; EBNA = Epstein-Barr Nuclear Antigen; RRMS = Relapsing remitting MS

^aPediatric-onset MS

^bage- and gender-matched healthy blood donors

^cvitamin D supplementation (n=27) and age- and gender-matched healthy blood donors

^dCorrelation between vitamin D levels and positive antibodies