TABLE 2.

Operating characteristics^a

Parameter evaluated	Operating characteristics of typing method(s)b
	MIRU-VNTR typing	Spoligotyping	Combined MIRU-VNTR-spoligotyping
Sensitivity	52 (31-72) [13/25]	83 (63-95) [20/24]	50 (29-71) [12/24]
Specificity	56 (51-62) [169/300]	40 (35-46) [120/298]	70 (65-76) [204/290]
PPV	9 (4-14) [13/144]	10 (6-14) [20/198]	12 (6-19) [12/98]
NPV	93 (90-97) [169/181]	97 (94-99.8) [120/124]	94 (91-98) [204/216]

^aTest characteristics of spoligotyping, MIRU-VNTR typing, and combined MIRU-VNTR-spoligotyping. Identical IS6110RFLP was used as the reference standard. When MIRU-VNTR and spoligotyping were used in combination, spoligotypes and MIRU-VNTRs both had to be identical for isolates to be considered clustered.

^bValues are percentages. Values in parentheses are 95% CIs. Values in brackets differ for each parameter and are as follows. Sensitivity is the number of isolates identical by the indicated typing method out of all isolates identical by IS6110 RFLP typing. Specificity is the number of isolates considered unique by the indicated typing method, out of all isolates unique by IS6110 RFLP typing. PPV is the number of isolates identical by IS6110 RFLP out of all isolates considered identical by the indicated typing method. NPV is the number of isolates unique by IS6110 RFLP out of all isolates considered unique by the indicated typing method.