Table 1.
Characteristics of Study Population, by concentration of hs-cTnT
| Below LOD | 3.0–4.25 ng/L | 4.26–5.87ng/L | 5.88–8.80 ng/L | ≥8.81 ng/L | Test for trend | |
|---|---|---|---|---|---|---|
| N | 1645 | 825 | 843 | 837 | 836 | |
| Range (ng/L) | <3.0 | 3.0–4.25 | 4.26–5.87 | 5.88–8.8 | 8.81+ | |
| Age | 56.8 (8.5) | 59.7 (9.5) | 62.1 (9.6) | 64.9 (9.4) | 68.7 (9.4) | <.001 |
| Male | 440 (26.8%) | 367 (44.5%) | 434 (51.5%) | 308 (36.8%) | 605 (72.4%) | <.001 |
| Ethnicity | <.001 | |||||
| Caucasian | 579 (35.2%) | 324 (39.3%) | 333 (39.5%) | 366 (43.7%) | 347 (41.5%) | |
| Chinese | 273 (16.6%) | 126 (15.3%) | 108 (12.8%) | 89 (10.6%) | 56 (6.7%) | |
| African-Am | 402 (24.4%) | 185 (22.4%) | 195 (23.1%) | 219 (26.2%) | 278 (33.3%) | |
| Hispanic | 391 (23.8%) | 190 (23.0%) | 207 (24.6%) | 163 (19.5%) | 155 (18.5%) | |
| Hypertension | 460 (28.0%) | 306 (37.1%) | 387 (45.9%) | 443 (52.9%) | 516 (61.7%) | <.001 |
| SBP (mm Hg) | 119.3 (19.2) | 122.6 (19.6) | 126.8 (20.8) | 130.4 (21.0) | 133.7 (23.2) | <.001 |
| DBP (mm Hg) | 69.9 (9.9) | 71.3 (10.4) | 72.8 (10.0) | 73.7 (10.0) | 73.3 (10.9) | <.001 |
| Diabetes Status | <.001 | |||||
| Normal | 1353 (82.4%) | 658 (79.9%) | 654 (77.7%) | 602 (72.2%) | 488 (58.4%) | |
| IFG | 180 (11.0%) | 108 (13.1%) | 94 (11.2%) | 117 (14.0%) | 146 (17.5%) | |
| Untreated DM | 28 (1.7%) | 13 (1.6%) | 26 (3.1%) | 21 (2.5%) | 34 (4.1%) | |
| Treated DM | 82 (5.0%) | 45 (5.5%) | 68 (8.1%) | 94 (11.3%) | 167 (20.0%) | |
| BMI (kg/m2) | 27.4 (5.2) | 27.5 (4.8) | 27.7 (4.9) | 28.2 (4.8) | 28.3 (4.8) | <.001 |
| Smoking | ||||||
| Never | 928 (56.5%) | 424 (51.5%) | 435 (51.7%) | 397 (47.7%) | 373 (44.8%) | <.001 |
| Former | 497 (30.3%) | 288 (35.0%) | 300 (35.6%) | 342 (41.1%) | 355 (42.7%) | |
| Current | 217 (13.2%) | 111 (13.5%) | 107 (12.7%) | 94 (11.3%) | 104 (12.5%) | |
| eGFR(CKD-Epi) | 84.3 (14.0) | 80.1 (14.5) | 77.6 (14.5) | 74.0 (14.5) | 69.9 (18.6) | <.001 |
| eGFR <60 mL/min/1.73m2 | 57 (3.5%) | 64 (7.8%) | 96 (11.4%) | 144 (17.3%) | 246 (29.5%) | <.001 |
| LDL-C (mg/dL) | 117.7 (31.0) | 116.9 (31.8) | 119.4 (31.1) | 1117.5 (30.4) | 113.6 (31.9) | .03 |
| HDL-C (mg/dL) | 53.1 (14.8) | 51.7 (15.7) | 51.2 (15.2) | 49.6 (14.0) | 48.6 (14.9) | <.001 |
| NT-proBNP (pg/mL) | 44.5 [20.4–79.6] | 43.3 [19.5–87.4] | 47.9 [21.2–94.9] | 55.9 [24.5– 13.4] | 84.2 [39.7–202.3] | <.001 |
| Very Good or Excellent Self-reported health | 880 (53.5%) | 427 (51.8%) | 399 (47.3%) | 413 (49.3%) | 382 (45.7%) | .001 |
| Medications: | ||||||
| Beta-blocker | 108 (6.6%) | 69 (8.4%) | 75 (8.9%) | 86 (10.3%) | 115 (13.8%) | <.001 |
| Diuretic | 108 (6.6%) | 107 (13.0%) | 94 (11.2%) | 127 (15.2%) | 173 (20.7%) | <.001 |
| ACEI or ARB | 143 (8.7%) | 96 (11.6%) | 139 (16.5%) | 151 (18.0%) | 221 (26.4%) | <.001 |
SBP: Systolic blood pressure; DBP: Diastolic blood pressure; IFG: Impaired fasting glucose; BMI: Body mass index; eGFR: Estimated Glomerular filtration rate