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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: Ann Neurol. 2017 Apr;81(4):560–571. doi: 10.1002/ana.24907

Figure 4. BMP regulates Dlx1/2 expression to govern interneuron cell fate in an Olig1-dependent manner.

Figure 4

(A) Representative images of adherent cultures derived from P7 wild type and Olig1-null mouse SVZs, differentiated for seven days in presence or absence of Noggin and stained for DCX, GABA and Olig2. (B) Cell counts of DCX, GABA and Olig2 in differentiated wild type and Olig1-null cultures. (C) Quantitative PCR from adherent cultures derived from P7 wild type mouse SVZ and cultured in the presence of BMP4, Noggin or BMP4+Noggin for six hours. (D) Schematic highlighting the mechanism by which BMP signaling regulates interneuron and oligodendrocyte cell fate in the postnatal SVZ. Data are mean ± s.e.m; n≥3 experiments; *P<0.05; **P<0.01; Dunnett’s multiple comparison test. (A) scale bar = 50μm.