Table 1.
SLE-like disease and LN in murine models with defects in cell death pathways
| Protein | Mouse model | Cell types affected | Presence of SLE-like disease | Presence of Lupus Nephritis |
|---|---|---|---|---|
| Extrinsic apoptotic pathway | ||||
| Fas | MRL.Faslpr | all cells | ++++ [114] | ++++ [114] |
| CD11ccreFasflox/flox | dendritic cells | ++ [120] | ? | |
| LysMcre/creFasflox/flox | monocytes/ macrophages/ neutrophils | ++ [121] | ++ [121] | |
| FADD | CD11ccreFADDflox/flox | dendritic cells | ++ [125] | ? |
| LysMcre/creFADDlox/flox | monocytes/ macrophages/ neutrophils | ++ [126] | ? | |
| FLIP | CD11ccreFlipflox/flox | dendritic cells | - [131] | ? |
| LysMcre/creFlipdel/flox | monocytes/ macrophages/ neutrophils | NA [136] | NA [136] | |
| LysMcre/+Flipdel/flox | monocytes/ macrophages/ neutrophils | - [136] | ? | |
| Caspase-8 | CD11ccreCasp8flox/flox | dendritic cells | +++ [147, 148] | +++ [147, 148] |
| LysMcre/creCasp8flox/flox | monocytes/ macrophages/ neutrophils | ++ [149] | - [149] | |
| Intrinsic apoptotic pathway | ||||
| Mcl-1 | Mcl-1 | all hematopoietic cells | - [160] | ? |
| Bcl2 | Vav(P)-Bcl2 | all hematopoietic cells | + [162] | ++ [161] |
| Bim | Bim−/− | all cells | +++ [167, 168] | +++ [167, 168] |
| Bim−/−.Faslpr | all cells | +++ [168] | +++ [168] | |
| Bim−/−Bmf−/− | all cells | +++ [169] | +++ [169] | |
| Necroptotic pathway | ||||
| RIPK3 | RIPK3−/− | all cells | - [187] | - [187] |
| Inhibitors of apoptosis | ||||
| IAPs | CD11ccrecIAP1flox/floxcIAP2−/− | dendritic cells | ? | ? |
| CD11ccrecIAP1flox/floxcIAP2−/−XIAP−/− | dendritic cells | ? | ? | |
| LysMcre/crecIAP1flox/floxcIAP2−/− | monocytes/ macrophages/ neutrophils | + [198] | ? | |
| LysMcre/crecIAP1flox/floxcIAP2−/−XIAP−/− | monocytes/ macrophages/ neutrophils | + [198] | ? | |