Table 4.
The association between LEP rs2167270 genotypes and clinical parameters
| Parameters | LEP rs2167270 genotype | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| GG n = 77 |
GA n = 95 |
AA n = 32 |
AA + GA n = 127 |
GG + GA n = 172 |
GG vs GA | GG vs AA | GA vs AA | GG vs AA + GA | GG + GA vs AA | |
| Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | p a | |||||
| BMI before pregnancy [kg/m2] | 24.6 ± 4.5 | 25.3 ± 6.0 | 25.8 ± 6.4 | 25.5 ± 6.1 | 25.0 ± 5.4 | 0.87 | 0.52 | 0.72 | 0.71 | 0.60 |
| BMI at birth [kg/m2] | 28.7 ± 4.6 | 29.5 ± 6.4 | 30.1 ± 7.0 | 29.6 ± 6.5 | 29.1 ± 5.6 | 0.93 | 0.74 | 0.67 | 0.84 | 0.68 |
| Weight increase during pregnancy [kg] | 11.0 ± 5.0 | 11.1 ± 4.8 | 11.6 ± 6.9 | 11.2 ± 5.4 | 11.1 ± 4.9 | 0.86 | 0.78 | 0.72 | 0.97 | 0.73 |
| BMI increase during pregnancy [kg/m2] | 4.1 ± 1.9 | 4.1 ± 1.8 | 4.3 ± 2.7 | 4.2 ± 2.1 | 4.1 ± 1.8 | 0.81 | 0.80 | 0.61 | 0.92 | 0.67 |
| HbA1c [%] | 5.54 ± 0.43 | 5.59 ± 0.51 | 5.52 ± 0.48 | 5.57 ± 0.50 | 5.57 ± 0.47 | 0.58 | 0.81 | 0.64 | 0.72 | 0.70 |
| Daily insulin requirement [unit] | 3.53 ± 9.41 | 6.26 ± 12.00 | 6.56 ± 13.88 | 6.34 ± 12.45 | 5.04 ± 10.97 | 0.019 | 0.14 | 0.74 | 0.019 | 0.66 |
| Gestational age at delivery [weeks pregnant] | 38.4 ± 2.3 | 38.6 ± 1.5 | 38.4 ± 2.1 | 38.5 ± 1.7 | 38.5 ± 1.9 | 0.66 | 0.95 | 0.68 | 0.75 | 0.79 |
| Newborn body mass [g] | 3250 ± 617 | 3276 ± 625 | 3271 ± 698 | 3275 ± 641 | 3264 ± 619 | 0.85 | 0.59 | 0.54 | 0.96 | 0.53 |
| APGAR | 9.8 ± 0.8 | 9.7 ± 1.1 | 9.5 ± 1.1 | 9.6 ± 1.1 | 9.7 ± 1.0 | 0.30 | 0.10 | 0.40 | 0.17 | 0.19 |
aMann–Whitney U test