Table 2.
Genotype distributions of female and male partners in the RPL cohort, according to clinically relevant pregnancy loss categories
| Index | Population controls | Parous controls | All RPL | Primary and secondary RPL | Tertiary RPL | |||
|---|---|---|---|---|---|---|---|---|
| n (%) | n (%) | Women n (%) |
Men n (%) |
Women n (%) |
Men n (%) |
Women n (%) |
Men n (%) |
|
| Genotypes | n = 360 | n = 166 | n = 232 | n = 141 | n = 179 | n = 107 | n = 53 | n = 34 |
| N/N | 208 (57.8) | 108 (65.1) | 119 (51.3) | 72 (51.1) | 88 (49.2) | 49 (45.8) | 31 (58.5) | 23 (67.6) |
| N/M2 | 134 (37.2) | 46 (27.7) | 105 (45.3) | 65 (46.1) | 83 (46.4) | 55 (51.4) | 22 (41.5) | 10 (29.4) |
| M2/M2 | 18 (5.0) | 12 (7.2) | 8 (3.4) | 4 (2.8) | 8 (4.5) | 3 (2.8) | 0 (0.0) | 1 (2.9) |
| M2 AF | 0.236 | 0.211 | 0.261 | 0.259 | 0.277 | 0.285 | 0.208 | 0.176 |
| M2 carriage | 152 (42.2) | 58 (34.9) | 113 (48.7) | 69 (48.9) | 91 (50.9) | 58 (54.2) | 22 (41.5) | 11 (32.3) |
RPL recurrent pregnancy loss, N “normal” allele including M1 heterozygous and homozygous combinations, AF allele frequency