Table 3.
Effect of analyzed compounds on fibrinolysis parameters—thromboelastometric data
Compounds | LOT (s) | LT (min) | LI30–LI45–LI60 (%) |
---|---|---|---|
Control | 1993 ± 111 | 48 ± 4 | 91–39–2 |
H–EACA–OH | ≥4084 | ≥168 | 100–98–92 |
H–EACA–NH2 | 2488 ± 172 | 71 ± 5 | 96–80–32 |
H–Ala–Phe–Lys–EACA–NH2 | 2731 ± 160 | 76 ± 6 | 99–86–43 |
H–D-Ala–Phe–Lys–EACA–NH2 | 2519 ± 176 | 72 ± 4 | 97–79–28 |
LOT lysis onset time—time from the start of coagulation to the point which the amplitude of formed clot is reduced by 15 % (s). LT lysis time, when clot is reduced/lysed by 90 % (s). LI30–LI45–LI60 Lysis index amplitude of clot (%) after 30, 45, 60 min (%). Control without synthesized peptides