Table 1.

Analysis of drug combination effects

Ricolinostat (µM)	Bendamustine (µM)	Effect	CI (CI 95%)
WSU-NHL
2	10	0.75	0.553 (0.307–0.996)
4	20	0.34	0.324 (0.116–0.900)
8	40	0.17	0.305 (0.091–1.46)
Hut-78
2	10	0.70	0.374 (0.313–0.446)
4	20	0.44	0.124 (0.079–0.193)
8	40	0.13	0.027 (0.011–0.067)
Jeko-1
2.5	25	59.6	1.13 (0.77–1.67)
5	50	13.3	0.04 (0.01–0.15)
10	100	13.7	0.02 (0.01–0.31)

Lymphoma cell lines were cultured with fixed doses of ricolinostat and bendamustine alone and in combination. Synergism, additivity, or antagonism were quantified by determining the CI calculated by the Chou–Talalay equation. Combination index (CI): CI < 1, synergism; CI = 1, additive effect; CI > 1, antagonis