Table 2.

Criteria used to classify ALGS subjects aged 10 years or older as having a mild or severe hepatic outcome

MILD	SEVERE
No overt clinical or biochemical evidence of liver disease	Death from complications of end-stage liver disease after age 5 years
Biochemical abnormalities without symptoms of cholestasis	Listed for or received a liver transplant after the age of 5 years
Symptoms of cholestasis (e.g. pruritus) adequately managed with medications	Cholestasis with significant complications (e.g. pathological bone fractures, pruritus requiring partial biliary diversion, etc.)
	Portal Hypertension (splenomegaly, esophageal or gastric varices, or ascites)