Table 2.

Ulcerative-colitis and dysplasia-related risk factors associated with progression of dysplasia in patients with low-grade dysplasia.

Outcome	Number of studies	Pooled OR with CI 65%	P value
Ulcerative colitis-related characteristics
Age at LGD diagnosis (per unit)	3	0.99 (0.96-1.02)	0.53
Age at UC diagnosis (per unit)	2	1.00 (0.96-1.03)	0.86
Disease Duration (per unit)	3	0.99 (0.96-1.02)	0.42
Male Sex	2	1.10 (0.57-2.12)	0.77
Concomitant PSC	3	3.42 (1.51-7.78)	<0.01
Dysplasia-related characteristics
Invisible dysplasia (vs visible dysplasia)	6	1.87 (1.04-3.36)	0.04
Distal location (vs proximal)	4	2.01 (1.10-3.65)	0.02
Multifocal dysplasia	3	3.54 (1.47-8.52)	<0.01
Persistent dysplasia (vs. Incident LGD)	2	1.36 (0.56-3.31)	0.50

Abbreviations: LGD, Low-grade dysplasia; OR, Odds ratio; PSC, Primary sclerosing cholangitis; UC, Ulcerative colitis