Table 1.

Sample Characteristics

Clinical Characteristics	All N=1296	No CMB N=1156	CMB N=140
Age (years) at exam closest to MRI	72±8	71±8	76±7
Men	46%	44%	55%
Follow up period, years, mean (SD)	6.7±2.7	6.8±2.7	5.8±2.8
Education No High School degree High School degree Some college College degree	5% 30% 30% 35%	5% 29% 31% 35%	5% 39% 27% 29%
Vascular risk factors
Systolic blood pressure, mm Hg	131±19	131±19	135±21
Diastolic Blood pressure, mm Hg	72±10	72±10	71±11
Hypertension	64%	62%	76%
Hypertension treatment	53%	52%	67%
Current smokers	6%	6%	6%
Diabetes	13%	13%	17%
Prevalent cardiovascular disease	20%	18%	35%
Total Cholesterol (mg/dL)	189±36	190±36	180±37
APOE Status
Any ε4 allele	21%	21%	26%
MRI
Log-White Matter Hyperintensities volume	−6.7 ± 1.2	−6.8 ± 1.1	−6.1 ± 1.3
Covert Brain infarcts	17%	15%	31%

Values are mean (SD) for continuous variables and n (%) for categorical variables.