Table 3.
All-cause dementia | Alzheimer Dementia | |||||
---|---|---|---|---|---|---|
Model 1 | Model 2 | Model 3 | Model 1 | Model 2 | Model 3 | |
CMB location | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) |
Any | 1.74 [1.00−3.01] P=0.049 |
1.44 [0.82−2.54] P= n.s. |
1.89 [1.04−3.44] P=0.038 |
1.92 [1.02−3.61] P=0.044 |
1.69 [0.88−3.25] P= n.s. |
2.30 [1.16−4.55] P=0.017 |
Lobar only | 1.01 [0.46−2.23] P= n.s. |
0.85 [0.38−1.90] P= n.s. |
0.89 [0.35−2.27] P= n.s. |
1.07 [0.42−2.73] P= n.s. |
0.95 [0.37−2.47] P= n.s. |
1.10 [0.38−3.15] P= n.s. |
Lobar + mixed | 1.48 [0.79−2.78] P= n.s. |
1.21 [0.63−2.31] P= n.s. |
1.51 [0.75−3.05] P= n.s. |
1.65 [0.79−3.44] P= n.s. |
1.43 [0.67−3.03] P= n.s. |
1.90 [0.86−4.22] P= n.s. |
Deep only | 2.50 [1.00−6.30] P=0.05 |
2.16 [0.85−5.48] P= n.s. |
2.85 [1.10−7.36] P=0.03 |
2.68 [0.95−7.52] P= n.s. |
2.55 [0.89−7.17] P= n.s. |
3.27 [1.12−9.59] P=0.03 |
Deep + mixed | 2.99 [1.52−5.90] P=0.002 |
2.44 [1.22−4.88] P=0.01 |
3.49 [1.72−7.10] P<0.001 |
3.29 [1.54−7.06] P=0.002 |
2.95 [1.36−6.42] P=0.006 |
4.15 [2.23−7.73] P<0.001 |
Reference group is no CMB. P= p-value, n.s. = non-significant, >0.05.
Model 1 adjusted for age, sex, education and APOE4.
Model 2 additionally adjusted for ischemic MRI markers: log-white matter hyperintensity volume, covert brain infarcts.
Model 3. Model 1 additionally adjusted for hypertension, diabetes, and prevalent cardiovascular disease