Table 3.

Cox Proportional Hazard Analysis of Risk of Incident dementia (all-cause and Alzheimer type) according to CMB presence and location

	All-cause dementia			Alzheimer Dementia
	Model 1	Model 2	Model 3	Model 1	Model 2	Model 3
CMB location	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)	HR (95% CI)
Any	1.74 [1.00−3.01] P=0.049	1.44 [0.82−2.54] P= n.s.	1.89 [1.04−3.44] P=0.038	1.92 [1.02−3.61] P=0.044	1.69 [0.88−3.25] P= n.s.	2.30 [1.16−4.55] P=0.017
Lobar only	1.01 [0.46−2.23] P= n.s.	0.85 [0.38−1.90] P= n.s.	0.89 [0.35−2.27] P= n.s.	1.07 [0.42−2.73] P= n.s.	0.95 [0.37−2.47] P= n.s.	1.10 [0.38−3.15] P= n.s.
Lobar + mixed	1.48 [0.79−2.78] P= n.s.	1.21 [0.63−2.31] P= n.s.	1.51 [0.75−3.05] P= n.s.	1.65 [0.79−3.44] P= n.s.	1.43 [0.67−3.03] P= n.s.	1.90 [0.86−4.22] P= n.s.
Deep only	2.50 [1.00−6.30] P=0.05	2.16 [0.85−5.48] P= n.s.	2.85 [1.10−7.36] P=0.03	2.68 [0.95−7.52] P= n.s.	2.55 [0.89−7.17] P= n.s.	3.27 [1.12−9.59] P=0.03
Deep + mixed	2.99 [1.52−5.90] P=0.002	2.44 [1.22−4.88] P=0.01	3.49 [1.72−7.10] P<0.001	3.29 [1.54−7.06] P=0.002	2.95 [1.36−6.42] P=0.006	4.15 [2.23−7.73] P<0.001

Reference group is no CMB. P= p-value, n.s. = non-significant, >0.05.

Model 1 adjusted for age, sex, education and APOE4.

Model 2 additionally adjusted for ischemic MRI markers: log-white matter hyperintensity volume, covert brain infarcts.

Model 3. Model 1 additionally adjusted for hypertension, diabetes, and prevalent cardiovascular disease