Table 1.
| A. Data on demographics, bowel habits and quantitative traits of subgroups based on either total fecal BA excretion per 48 hrs or fasting serum C4 (mean ± SE) | ||||
|---|---|---|---|---|
| Total fecal BAs ≥2337 µmoles per 48 hrs |
Total fecal BAs <2337 µmoles per 48 hrs |
Serum C4 ≥47.1 ng/ml | Serum C4 <47.1 ng/ml | |
| N | 24 | 86 | 19 | 91 |
| Age, years | 39.0±2.4 | 42.0±1.2 | 46.7±2.7 | 40.2±1.2 |
| BMI, kg/m2 | 32.0±1.5 | 26.6±0.6 | 31.7±2.1 | 26.9±0.6 |
| # bowel movements/day | 2.22±0.24 | 1.51±0.10 | 1.90±0.22 | 1.62±0.11 |
| Mean stool consistency (BSFS) | 4.61±0.19 | 3.91±0.12 | 4.33±0.28 | 4.01±0.12 |
| Fecal fat (g/24 hrs) | 11.4±8.9 | 6.5±0.6 | 7.8±1.3 | 7.6±0.7 |
| Total stool weight (g/48 hrs) | 557.7±55.4 | 256.8±16.9 | 357.1±43.7 | 316.3±24.3 |
| Total fecal BA excretion (µmoles/48 hrs) |
4839±744 | 728.8±69 | 2573±627 | 1428±248 |
| Total fecal BA concentration (mM) | 9.6±1.1 | 3.2±0.3 | 8.2±1.6 | 3.9±0.4 |
| % fecal CDCA and CA | 16.9±4.1 | 4.5±0.9 | 8.8±2.5 | 6.9±1.4 |
| % fecal CDCA and DCA | 61.3±1.9 | 55.0±1.7 | 64.7±2.2 | 54.7±1.6 |
| Serum C4, ng/mL | 37.7.±4.6 | 25.5±2.5 | 71.0±4.9 | 19.2±1.1 |
| Colonic transit GC24 | 3.2±0.2 | 2.5±0.1 | 3.1±0.3 | 2.5±0.1 |
| Colonic transit GC48 | 4.5±0.2 | 3.7±0.1 | 4.4±0.3 | 3.8±0.1 |
| AC emptying t1/2(hr) | 13.5±1.8 | 16.1±0.9 | 13.6±2.3 | 15.9±0.9 |
| B. Data for patients who had normal or abnormal values of both total fecal BA excretion per 48 hrs or fasting serum C4 | ||
|---|---|---|
| Total BAs ≥2337 µmoles/48 hrs and serum C4>47.1 ng/mL |
Total BAs <2337 µmoles/48 hrs and serum C4<47.1 ng/mL |
|
| N | 36 | 74 |
| Age, years | 39.0±2.4 | 41.1±1.3 |
| BMI, kg/m2 | 32.0±1.5 | 25.6±0.5 |
| # bowel movements/day | 2.22±0.24 | 1.41±0.10 |
| Mean stool consistency (BSFS) | 4.61±0.19 | 3.81±0.13 |
| Fecal fat (g/24h) | 11.4±8.9 | 6.3±0.6 |
| Total stool weight (g/48h) | 557.7±55.4 | 246.2±17.7 |
| Total fecal BA excretion (µmoles/48h) | 4839±744 | 656.1±68.8 |
| Total fecal BA concentration (mM) | 9.6±1.1 | 3.0±0.3 |
| % fecal CDCA and CA | 16.9±4.1 | 4.0±0.9 |
| % fecal CDCA and DCA | 61.3±1.9 | 53.3±1.8 |
| Serum C4, ng/mL | 49.4±4.8 | 17.8±1.1 |
| Colonic transit GC24 | 3.2±0.2 | 2.4±0.1 |
| Colonic transit GC48 | 4.5±0.2 | 3.6±0.1 |
| AC emptying t1/2(hr) | 13.5±1.8 | 16.4±1.0 |
BAs, bile acids; BMI, body mass index; BSFS, Bristol stool form scale; CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; GC, geometric center; AC, ascending colon