Table 2.

Concentrations of total and estimated concentrations of main fecal BAs in IBS-D and healthy controls (mean ± SE)

	IBS-D with total fecal BA <2337µmoles/48h		IBS-D with serum C4 <47.1 ng/ml		IBS-D total fecal BAs <2337 µmoles / 48 hrs and serum C4 <47.1 ng/ml		Healthy controls
N=	86		91		74		30
	% of total fecal BAs	Concentration in stool (mM)*	% of total fecal BAs	Concentration in stool (mM)*	% of total fecal BAs	Concentration in stool (mM)*	% of total fecal BAs	Concentration in stool (mM)*
Total fecal BAs		3.2±0.3		3.9±0.4		3.0±0.3		3.0±0.5
CDCA	2.19±0.4	0.07	3.05±0.5	0.12	2.02±0.5	0.06	0.5±0.1	0.015
CA	2.33±0.5	0.07	3.88±0.9	0.15	2.00±0.5	0.06	0.6±0.2	0.018
LCA	41.14±1.9	1.30	39.62±1.9	1.52	43.30±2.0	1.29	39.0±2.8	1.17
DCA	52.76±1.7	1.67	51.6±1.6	1.99	51.3±1.9	1.54	59.2±2.7	1.78
UDCA	1.58±0.3	0.05	1.82±0.3	0.07	1.37±0.3	0.04	0.7±0.3	0.021

^*Concentrations of individual bile acids were based on mean percent of total fecal BAs multiplied by mean concentration of total fecal BAs actually measured in stool.

BAs, bile acids; IBS-D, diarrhea-predominant irritable bowel syndrome; CA, cholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; LCA, lithocholic acid; UDCA, ursodeoxycholic acid