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. 2017 Mar 31;22(1):1–5. doi: 10.6065/apem.2017.22.1.1

Table 2. Main conditions potentially causing an altered bone density and/or quality in childhood.

Classification Disease
Endocrine diseases Hypogonadism; insensitivity syndrome of estrogen; panhypopituitarism; growth hormone deficiency; hyperthyroidism; Cushing syndrome; primary hyperparathyroidism; primary hypoparathyroidism; McCune-Albright syndrome
Iatrogenic causes Anticonvulsants; gonadotropin-releasing hormone analogue; L-thyroxine (high dose); antiretroviral drugs; anticoagulants; chemotherapeutic drugs; corticosteroids treatments
Genetic syndromes Turner syndrome; Klinefelter syndrome; 22q11 deletion syndrome; Down syndrome; Williams-Beuren syndrome
Malignancies Leukemia; lymphoma; solid tumors
Nutritional problems Nervous anorexia; lactose intolerance; deficiency of calcium, copper, etc.; vegetarian diets; malnutrition; total parenteral nutrition
Chronic diseases Juvenile idiopathic arthritis; systemic lupus erythematosus; dermatomyositis; chronic renal failure; renal tubular acidosis; idiopathic hypercalciuria; cholestatic forms; celiac disease; Crohn disease; ulcerative Colitis; congestive heart failure; thalassemia; hereditary hemochromatosis; haemophilia; sickle cell anemia; systemic mastocytosis; hyper-IgE syndrome; overweight/obesity
Other Immobilization/little use; intense physical activity; posttransplant; prematurity