Table 1. Pharmacokietic parameters of glucagon-like peptide 1 (GLP-1) receptor agonists approved by U.S. Food and Drug Administration.

Drug	Half life	Brand name	Dosing frequency	US FDA approved	Cmax	Tmax	Reference
GLP-1	<2 Mo	-	-	-	-	-	67,68)
Exenatide	2–4 Hr	Byetta	Twice daily	Apr, 28. 2005	211 pg/mL	1.5 Hr	97)
Extended-release exenatide	2–4 Hr	Bydureon	Once weekly	Jan, 26, 2012	211 pg/mL	1.5 Hr	97)
Liraglutide	13 Hr	Victoza	Once daily	Jan, 25, 2010	35 ng/mL	8–12 Hr	83)
Albiglutide	5 Days	Tanzeum (US) Eperzam (EU)	Once weekly	Apr, 15, 2014	1.74 µg /mL	3–5 Days	98)
Dulaglutide	5 Days	Trulicity	Once weekly	Sep, 18, 2014	114 ng/mL	48 Hr	99)