TABLE 1.
Frequency of amino acid polymorphism in the PR in naive HIV-2-infected patients compared to consensus sequences for HIV-1 clade B and HIV-2 subtypes A and B
| Position | HIV-1 clade B consensus | HIV-2 clade A consensus | Substitution(s) (position and amino acid)a | HIV-2 clade B consensus | Substitution(s) (position and amino acid)a | % |
|---|---|---|---|---|---|---|
| 7 | Q | K | 7N (1) | # | 1 | |
| 8 | R | R | 8K (1) | 1 | ||
| 9 | P | P | 9T (1) | 1 | ||
| 10 | L | V | 10I (4) | V | 101 (2), 10R (1) | 7 |
| 11 | V | V | 11S (1) | 1 | ||
| 12 | T | T | 12I (2) 12R (1) | K | 12Q (3), 12R (1), 12K/Q (1) | 8 |
| 14 | K | Y | 14H (38), L (1), P (2) | C | 14H (3), 14N (6), 14S (3), 14S/N (1) | 54 |
| 15 | I | I | 15V (7), 15F (1) | I | 15V (2) | 10 |
| 17 | G | G | 17D (20), 17K/D/E (1), 17E (2) | G | 17D (1) | 24 |
| 18 | Q | Q | 18K (1) | 1 | ||
| 20 | K | V | 20I (1) | 1 | ||
| 21 | E | E | 21D (1) | E | 21D (1) | 2 |
| 22 | A | V | 22I (1) | 1 | ||
| 35 | E | G | 35E (1) | 1 | ||
| 36 | M | I | 36V (4) | 4 | ||
| 37 | N | E | 37D (1) | 1 | ||
| 40 | G | S | 40D (15), 40N (10), 40G/D (1), 40E/D (2), 40E (1) | S | 40N (1) | 30 |
| 41 | R | N | 41D (14) | N | 41D (7) | 21 |
| 43 | K | S | 43V/I (1), 43N (2), 43I (1), 43R (1), 43V (1) | T | 43I (1) | 7 |
| 44 | P | P | 44S (1) | 1 | ||
| 45 | K | K | 45R (2) | 2 | ||
| 46 | M | I | 46V (7), 46M (1) | 8 | ||
| 54 | I | I | 54M (2) | I | 54M (1) | 3 |
| 56 | V | T | 56A (1), 56V (1) | 2 | ||
| 57 | R | K | 57R (2) | 2 | ||
| 60 | D | K | 60R (4), 60E (1) | K | 60R (2) | 5 |
| 61 | Q | D | 61V/I (1) | 1 | ||
| 62 | I | V | 62I (2), 62A (1) | V | 62I (9) | 12 |
| 65 | E | K | 65R (7), 65I (2), 65T (1) | 10 | ||
| 66 | I | V | 66A (1) | 1 | ||
| 68 | G | N | 68S (1) | 1 | ||
| 70 | K | R | 70K (19), 70T (3) | R | 70I (1), 70K (2), 70V (1) | 26 |
| 71 | A | V | 71I (2), 71I/L (1) | V | 71I (7), 71L (1) | 11 |
| 72 | I | R | 72K (5) | 5 | ||
| 73 | G | A | 73G (1) | 1 | ||
| 74 | T | T | 74N (1) | 1 | ||
| 75 | V | I | 75R (1), 75L (1) | I | 75V (3), 75L (2) | 7 |
| 77 | V | T | 77M/I (1) | 1 | ||
| 79 | P | D | 79E (2) | 2 | ||
| 85 | I | F | 85L (1) | 1 | ||
| 86 | G | G | 86A (1) | 1 | ||
| 87 | R | R | 87E (1) | 1 | ||
| 89 | L | I | 89V (4), 89D/E (1) | 5 | ||
| 90 | L | L | 90S/L (2), 90L/M (1) | 3 | ||
| 91 | T | T | 91A (9) | N | 91S (1) | 10 |
| 92 | Q | A | 92S (4), 92V (2) | T | 92I (1), 92S (7) | 14 |
| 95 | C | F | 95I (1) | 1 |
a
Values in parentheses are numbers of patients.