62 y/o female with 12 cm unresectable, infiltrative ICC, >50% liver involvement. (A) CT prior to Y-90 resin administration; (B) angiogram on day of Y-90 resin treatment. Patient received right lobe SIRT on 11/2012, 12/2012, 8/2013 and 8/2014. She received left lobe medial segment SIRT on 12/2014; (C) CT 3+ years after initial Y-90 resin treatment. Radiation necrosis in prior site of 12 cm ICC. Compensatory hypertrophy left lobe. ICC, intrahepatic cholangiocarcinoma.