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. 2017 Apr 24;8:129. doi: 10.3389/fneur.2017.00129

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Copyright © 2017 Cui, Zhou, Wang, Lang, Park, Tan, Yu, Sun, Gao and Kong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) In both RRMS1 and RRMS2 cohorts, the left dorsal caudal putamen (DCP) showed significantly increased FC with the left premotor cortex, dorsal lateral prefrontal cortex (DLPFC), insula, precuneus, and superior parietal lobule compared to healthy controls (HCs). (B) Overlapping regions of between-group comparisons and associations between the Expanded Disability Status Scale (EDSS) and left DCP FC at the DLPFC in the RRMS1 cohort. (C) Overlapping regions of between-group comparisons and associations between the EDSS and left DCP FC at the DLPFC and parietal areas in the RRMS2 cohort.